Innogenics is a specialty genomics reference laboratory that helps veterinarians and owners of pets with cancer by providing state-of-the-art molecular diagnostic analysis of tumor tissue at costs affordable to the pet owner. We provide a molecular profile of a dog’s tumor that details the cancer type and subtype and provides biomarker information useful in guiding decisions about current and novel therapeutic options.
At its core, cancer is a genetic disease. Unregulated growth, inappropriate growth signals, blunted or absent response to “death” signals—all of these characteristics are regulated by genes. For this reason, the promise of genomics in oncology is huge. The expectation of improved diagnostics, prognostics and therapeutics is shared by patients and oncologists alike.
At its core, cancer is a genetic disease. Unregulated growth, inappropriate growth signals, blunted or absent response to “death” signals—all of these characteristics are regulated by genes. For this reason, the promise of genomics in oncology is huge. The expectation of improved diagnostics, prognostics and therapeutics is shared by patients and oncologists alike.
Gene
expression analysis is widely used in human oncology.
In the
diagnostic phase of oncology, we certainly understand that an accurate
diagnosis is necessary in order to prescribe the optimal therapy. A fantastic
paper published in the Proceedings of the National Academy of Sciences (http://www.pnas.org/content/98/26/15149.short)
reported that gene profiling was incredibly accurate in determining the type of
cancer spanning 14 of the most common cancers. In addition, gene expression
analysis showed that undifferentiated cancers based upon histology had gene
expression patterns unlike their tissue of origin. The dramatically different
gene expression accurately predicts the aggressive, abnormal biologic behavior
of these tumors, similar to what most oncologists observe in the clinic.
Gene
expression patterns can also aid in the prognostic phase of oncology. Accurate
prognostication is important, as it allows the clinician to identify patients
who will likely do well or those who will do poorly. In a highly cited paper in
Nature (http://www.nature.com/nature/journal/v415/n6871/full/415530a.html)
the authors evaluate the gene expression pattern of 117 patients and they were
able to conclude that “This gene expression profile will outperform all
currently used clinical parameters in predicting disease outcome. Our findings
provide a strategy to select patients who would benefit from adjuvant therapy.”
The number of genes that need to be
evaluated does not have to be large. In one paper (http://www.sciencedirect.com/science/article/pii/S1535610804001412) the authors prove that the ratio of only
TWO genes was prognostic in breast cancer patients. As a clinician, the
question of how will MY pet do is one I hear every day. Wouldn’t it be
wonderful to be able to accurately answer these pet owners?
When it comes to the cancer that is most treated in the veterinary world,
lymphoma, can gene expression analysis help? The answer is a resounding yes.
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma in
dogs and is very similar to DLBCL in humans. Gene expression analysis has
proven useful in this disease for BOTH dogs and people (http://cancerres.aacrjournals.org/content/73/16/5029.abstract and http://www.nature.com/nature/journal/v403/n6769/full/403503a0.html). By routinely performing gene expression
analysis on the lymphomas that we diagnose in dogs, it is possible, indeed
expected, that therapy will be more effective. And at the end of the day, isn’t
more effective therapy what we all want?
Gerald Post, DVM, MEM, DACVIM (Oncology)
Gerald Post, DVM, MEM, DACVIM (Oncology)
